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Drug Detoxification Research Studies

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Drug Detoxification Method - Scientific Literature

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Drug Detoxification References

1. Stanley JS (1986) Broad Scan Analysis of Human Adipose Tissue: Volume 1: ExecutiveSummaryEPA 560/5-86-035.


2. Axelrod J, Brady RO, Witkop B and Evarts EV (1957) The distribution and metabolism of lysergic acid diethylamide. Ann NYAcadSci 66:435-444.


3. Stolman A (1974) The absorption, distribution, and excretion of drugs and poisons and their metabolites. In: Progress in Chem Tox, Vol. 5, A Stolman, ed., Academic Press, pp 1-99.


4. James SH and Schnoll SH (1976) Phencyclidine: Tissue distribution in the rat. Clin Tox9:573-582.

5. Nayak PK, Misra AL and Mule SJ (1976) Physiological disposition and biotransformation of [3H]cocaine in acutely and hronically treated rats. / Pharmacol & Exper Ther 196:556-569.


6. Rodger L. Foltz, Ph.D., Personal communication.


7. Friedman H, Ochs HR, Greenblatt DJ and Shader RI (1985) Tissue distribution of diazepam and its metabolite smethyldiazepam: A human autopsy study. J Clin Pharmacol 25:613-615.


8. Dackis CA, Pottash ALC, Annitto W and Gold MS (1982) Persistence of urinary marijuana levels after supervised abstinence. Am JPsychiatry 139:1196-1198.


9. Martin BR (1982) Long-term disposition of phencyclidine in mice. Drug Metabolism and Disposition 10:189-193.


10. Weiss RD (1988) Protracted elimination of cocaine metabolites in long-term, high-dose cocaine abusers. AmerJMed85:879-880.


11. Cone EJ and Weddington Jr. WW (1989) Prolonged occurrence of cocaine in human saliva and urine after chronic use. J Analytical Toxicol 13:65-68.


12. Ramazzini, B (1713) Diseases of Workers, New York Academy of Medicine, History of Medicine Series, Vol. 23, Hafner Publishing Co., New York, 1964.


13. Guzelian PS (1982) Chlordecone poisoning: A case study in approaches of detoxification of humans exposed to environmental chemicals. Drug Metab Reviews 13:663-679.


14. Ricks R et al. (1989) The Radiological Accident in Goiania, Unipub Publications, Lanham, MD. (Reported by Hixson JR in Medical Tribune, Thursday, September 22, 1988)


15. Imamura M, TungT-C (1984) A trial of fasting cure for PCB poisoned patients in Taiwan. Am JIndMed 5:147-153.


16. Chisolm Jr. JJ (1968) The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood. J Pediatrics 73:1-38.


17. Wedeen RP, Batuman V and Landy E (1983) The safety of the EDTA lead-mobilization test. EnvResearch 30:58-62.


18. Bulow J (1983) Adipose tissue blood flow during exercise. Danish Medical Bulletin 30(2):85-100.


19. Friedberg SJ, Harlan Jr. WR, Trout DL, Estes Jr. EH (1960) The effect of exercise on the concentration and turnover of plasma nonesterified fatty acids. J Clin Invest 39:215.


20. Carlson LA and Pernow B (1961) Studies on blood lipids during exercise. JLab and Clin Med 58:673-681.


21. Friedberg SJ, Sher PB, Bogdonoff MD and Estes Jr. EH (1963) The dynamics of plasma free fatty acid metabolism during exercise. J Lipid Research 4:34-38.


22. Horstman D, Mendez J, Buskirk ER, Boileau R and Nicholas WS (1971) Lipid metabolism during heavy and moderate exercise. MedandSci in.Sp0/-ft3:18-23.


23. Taylor AW, Shoemann DW, Lovlin R and Lee S (1971) Plasma free fatty acid mobilization with graded exercise. J Sports Med 11:234-240.


24. Wirth A, Schlierf G and Schetler G (1979) Physical activity and lipid metabolism. Klin Wochenshri 57:1195.


25. Findlay GM and de Freitas ASW (1971) DDT movement from adipocyte to muscle cell during lipid utilization. Nature 229:63.


26. de Freitas AS and Norstrom RJ (1974) Turnover and metabolism of polychlorinated biphenyls in relation to their chemical structure and the movement of lipids in the pigeon. Can JPhysiol Pharmacol 52:1081-1094.


27. Mitjavila S, Carrera G and Fernandez Y (1981) II. Evaluation of the toxic risk of accumulated DDT in the rat: During fat mobilization. Arch Environ Contain Toxicol 10:471-481.


28. Seba DB (1990) Thermal chamber depuration: A perspective on man in the sauna. Clinical Ecology 7:1-12.


29. Henderson GL and Wilson BK (1973) Excretion of methadone and metabolites in human sweat. Res Comm Chem Path & Pharmac5'.l-8.


30. Vree TB, Muskens ATJM, and Van Rossum JM (1972) Excretion of amphetamines in human sweat. Arch Int Pharmacodyn 199:311-317.


31. Ishiyama I, Nagai T, Nagai T, Komuro E, Momose T and Akimori N (1979) The significance of drug analysis of sweat in respect to rapid screening for drug abuse. ZKechtsmed82'.25l-256.


32. Sunderman Jr. FW, Hohnadel DC, Evenson MA, Wannamaker BB and Dahl DS (1974) Excretion of copper in sweat of patients with Wilson's disease during sauna bathing. Ann Clinic Lab Sci 4:407.


33. Stopford W (1979) Industrial exposure to mercury. In: The Biogeochemistry of Mercury in the Environment, Elsevier/North-Holland Biomedical Press, pp 367-397.


34. Hohnadel DC, Sunderman FW, Nechay MW and McNeely MD (1973) Atomic absorption spectrometry of nickel, copper, zinc, and lead in sweat collected from healthy subjects during sauna bathing. Clinical Chemistry 19:1288-1292.


35. Abe T, Mayuzumi J, Kikuchi, Arai S (1980) Seasonal variations in skin temperature, skin pH, evaporative water loss and skin surface lipid values on human skin. Chem Pharm Bull28:387-392.


36. Kimbrough RD (1974) The toxicity of polychlorinated polycyclic compounds and related chemicals. CRC Critical Rev Toxicol 2:445-499.


37. Kimbrough RD (1980) Occupational exposure. In: Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products, Kimbrough RD, ed., Elsevier/North Holland Biomedical Press, Amsterdam, pp 373-399.


38. Tretjak Z, Shields M and Beckmann SL (1990) PCB reduction and clinical improvement by detoxification: An unexploited approach? Human and Experimental Toxicology 9:235-244.


39. Carlson LA (1970) Nicotinic acid: its metabolism and its effects on plasma free fatty acids. In: Metabolic Effects of Nicotinic Acid and its Derivatives, Gey KF and Carlson LA, eds., Hans Huber, Switzerland, pp 157-165.


40. Carlson LA, Oro L and Ostman J (1968) Effect of a single dose of nico-tinic acid on plasma lipids in patients with hyperlipoproteinemia. Acfa med scand 183:457-465.


41. Nye ER and Buchanon B (1969) Short-term effect of nicotinic acid on plasma level and turnover of free fatty acids in sheep and man. J Lipid Research 10:193-196.


42. Smith RL (1973) Implications of Biliary Excretion (Chapter 8), In: The Excretory Function of Bile, Chapman and Hall, Ltd., London.


43. Parker RJ, Hirom PC and Millburn P (1980) Enterohepatic recycling of phenolphthalein, morphine, lysergic acid diethylamide (LSD) and diphenylacetic acid in the rat. Hydrolysis of glucuronic acid conjugates in the gut lumen. Xenobiotica 10:689-703.


44. Moore RB, Anderson JT, Taylor HL, Keys A and Frantz ID (1968) Effect of dietary fat on the fecal excretion of cholesterol and its degradation products in man. J Clinical Investigation 47:1517-1534.


45. Shepherd], Stewart JM, ClarkJG and Carr K (1980) Sequential changes in plasma lipoproteins and body fat composition during polyunsat-urated fat feeding in man. Br J Nutr 44:265-271.


46. Bonjour JP (1980) Vitamins and Alcoholism. Internal J Vit NutrRes 50:215-230:307- 338; 51:166-177.


47. Russell RM (1980) Vitamin A and zinc metabolism in alcoholism. Am JClinNut 33:2741-2749.


48. Roe, DA (1984) Nutrient and drug interactions. Nutrition Reviews 42:141-154.


49. Innami S, Nakamura A, Miyazaki M, Nagayama S and Nishide E (1977) Further studies on the reduction of vitamin A content in the livers of rats given polychlorinated biphenyls. JNutr Sci I^'fa/77/no/22:409-418.


50. Kato N, Kato M, Kimura T and Yoshida A (1978) Effect of dietary addition of PCB, DDT or HGT and dietary protein on vitamin A and cholesterol metabolism. Nutr Rep Int 18:437-445.


51. Brin M and Roe D (1979) Drug-diet interactions. J Florida MA 66:424-428.


52. Schnare DW, Denk G, Shields M and Brunton S (1982) Evaluation of a detoxification regimen for fat stored xenobiotics. MedHyp 9:265-282.


53. Schnare DW and Robinson PC (1986) Reduction of human body burdens of hexachlorobenzene and polychlorinated biphenyls. In Hexachlorobenzene: Proceedings of an International Symposium, CR Morris and JRP Cabral, eds., International Agency for Research on Cancer, Lyon, France, pp 597-603.


54. Roehm D (1983) Effects of a program of sauna baths and megavita-mins on adipose DDE and PCBs and on clearing of symptoms of Agent Orange (dioxin) toxicity. Clin fe31(2):243a.


55. Schnare DW, Ben M and Shields MG (1984) Body burden reductions of PCBs, PBBs and chlorinated pesticides in human subjects. Ambio 13:378-380.


56. Wolff MS, Anderson HA and Selikoff IJ (1982) Human tissue burdens of halogenated aromatic chemicals in Michigan. JAMA 247:2112-2116.


57. Tretjak Z, Beckmann S, Tretjak A and Gunnerson C (1989) Occupational, environmental, and public health in Semic: A case study of polychlorinated biphenyl (PCB) pollution. In Post-Audits of Environmental Programs & Projects, C Gunnerson, ed., ASCE, New York, NY, pp 57-72.


58. Tretjak Z, Root DE, Tretjak A, Slivnik R, Edmondson E, Graves R and Beckmann SL (1990) Xenobiotic reduction and clinical improvements in capacitor workers: A feasible method. J Env Sci and Health, A25:731-751.


59. Root DE and Lionelli GT (1987) Excretion of a lipophilic toxicant through the sebaceous glands: A case report. / Toxicol - Cut & Ocular


60. Kilburn KH, Warsaw RH and Shields MG (1989) Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs): Possible improvement after detoxification. Arch Env Health 44:345-350.


61. Shields M, Beckmann SL and Cassidy-Brinn G (1989) Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs, PCDDs and PCDFs. Clinical Ecology 6:47-50.


62. Root DE, Katzin DB, Schnare DW (1985) Diagnosis and treatment of patients presenting subclinical signs and symptoms of exposure to chemicals which bioaccumulate in human tissue. In: Proceedings of the National Conference on Hazardous Wastes and Environmental Emergencies, May 14-16.



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